Coden: Ijpnl6 Impact of Furfural and Kerosene Coexposure through Inhalation in Lungs of Rats

Furfural is being added to kerosene to check the adulteration of gasoline/high speed diesel oil. The possibility of a co-exposure of furfural and kerosene and the ability to exhibit the toxic effects of such a mixture were examined in view of the toxicity potential of the two alone and in combination with each other. A single inhalation exposure of rats to furfural was fully tolerated up to a concentration of 126 ppm. However, exposure to higher concentrations of furfural resulted in a dose dependent mortality. Exposure of rats to vapor of kerosene ranging from 426-1054 ppm did not show toxic signs and mortality up to a period of seven days. Simultaneous exposure of rats to furfural and kerosene vapors ranging in concentration from 35 ppm to 138 ppm showed a suppression of LC50 value of furfural. The LC50 was 105 ppm in rats exposed to furfural-kerosene vapors. Inhalation exposure of rats to 1⁄2 LC50 of furfural to 95 ppm, 1 hr daily, 5 days/week over a period of 28 days caused severe irritation of eyes and nose leading to lacrimation, perinasal and perioral wetness, labored breathing and mild nasal bleeding. Neither the body weight nor lung weight showed any change as compared to the control group. Activities of acid and alkaline phosphatase, glutamic pyruvic and glutamic oxaloacetic transaminases, succinic dehydrogenase, total sulphydryl content and lactic acid content were evaluated.